Urinary methylmalonic acid excretion [letter]

Urinary methylmalonic acid excretion.

Effect of vitamin B12 derivatives on urinary excretion of methylmalonic acid in liver diseases.

1. Twenty.one patients with liver diseases were studied for their urinary mehylmalonic acid excretion after a valine load by means of an improved thin layer chromatography. 2. Methylmalonic acid positive cases were found in four out of the ten patients with cirrhosis of the liver, all four with cirrhosis and diabetes mellitus, and none with acute hepatitis of icteric phase. No apparent correlat...

Studies on methylmalonic acid in humans. II. Relationship between concentrations in serum and urinary excretion, and the correlation between serum cobalamin and accumulation of methylmalonic acid.

Methylmalonic acid (MMA) concentrations are increased in cobalamin (vitamin B12) deficiency, but the relative diagnostic usefulness of determination of MMA in serum vs urine has not yet been assessed. We obtained urine collections and matched serum samples from 28 healthy volunteers and from 20 consecutive patients admitted for clinical and hematological evaluation because of low cobalamin conc...

Gastric acid and urinary acid excretion.

1 Saverymuttu SH, Peters AM, Lavender PJ, Hodgson HJ, Chadwick VS. "'Indium autologous leucocytes in inflammatory bowel disease. Gut 1983; 24: 293-9. 2 Bernstein J. Colonic ulceration and bleeding during diclofenac therapy. N Engl J Med 1990; 323: 135. 3 Bjarnason I, Price AB. Effect of NSAID on the large bowel. GI Futures and Clin Pract 1988; 3: 7-10. 4 Rampton DS. NSAID and the lower gastroin...

Urinary methylmalonic acid in patients with acute myocardial infarction.

OBJECTIVE To investigate urinary methylmalonic acid (uMMA) levels and their relationship with markers of myocyte necrosis and inflammation in patients with acute myocardial infarction (AMI). SUBJECTS AND METHODS The study participants consisted of 80 consecutive patients with AMI and 72 age- and sex-matched consecutive controls. Of the patients, 38 had ST segment elevation myocardial infarcti...